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MSGene - Gene overview of all published MS-association studies for CD6
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 Gene: CD6  (FLJ44171; TP120)  Entrez Gene
 Protein: CD6 molecule  (CD6 antigen; T-cell differentiation antigen CD6; T12)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
De Jager, 2009
GWAS meta-analysis CL  1  (detail)  -MD1----Positive
De Jager, 2009
UK CL  1  (detail)  831
(70%)
MD132
(10-67)
46
(-)
1030
(-)
-Positive
De Jager, 2009
USA (UCSF) CL  1  (detail)  407
(-)
MD142
(3-60)
54
(-)
142
(-)
-Positive
De Jager, 2009
USA (BWH,WU,ACP,RUSH) CL  1  (detail)  976
(-)
MD1--944
(-)
-Positive
IMSGC, 2011
Belgium CL  1  (detail)  1021
(64%)
O/M--776
(52%)
-Positive
IMSGC, 2011
Denmark CL  1  (detail)  1090
(67%)
O/M--634
(62%)
-Negative
IMSGC, 2011
Finland CL  1  (detail)  1077
(71%)
O/M--792
(58%)
-Positive
IMSGC, 2011
Germany CL  1  (detail)  911
(-)
O/M--930
(-)
-Negative
IMSGC, 2011
Italy CL  1  (detail)  629
(67%)
O/M--828
(50%)
-Negative
IMSGC, 2011
Norway CL  1  (detail)  1027
(72%)
O/M--662
(67%)
-Negative
IMSGC, 2011
Spain CL  1  (detail)  501
(64%)
O/M--501
(52%)
-Negative
IMSGC, 2011
Sweden CL  1  (detail)  1723
(71%)
O/M--2016
(67%)
-Positive
IMSGC, 2011
UK CL  1  (detail)  714
(74%)
O/M--656
(74%)
-Negative
IMSGC, 2011
USA CL  1  (detail)  587
(52%)
O/M--644
(52%)
-Positive
Sanna, 2010
Italy-Sardinia (GWAS) CL  1  (detail)  882
(-)
MD1--872
(-)
-Negative
Swaminathan, 2010
Spain (Bilbao) CL  1  (detail)  592
(73%)
P30.5 + 10.1
(7-66)
-567
(69%)
-Positive
Swaminathan, 2010
Spain (Andalucia) CL  1  (detail)  1021
(69%)
P31.5 + 10.7
(13-68)
-1276
(67%)
-Positive
Swaminathan, 2010
Spain (Madrid) CL  1  (detail)  652
(63%)
P28.8 + 8.9
(3-56)
-850
(53%)
-Positive
Swaminathan, 2010
Spain (San Sebastian) CL  1  (detail)  250
(62%)
P31.6 + 10.3
(12-68)
-249
(66%)
-Positive
 African Descent
Johnson, 2009
USA CL  2  (detail)  918
(79%)
MD1--656
(71%)
-Positive
 Other/Mixed
Pandit, 2010
India CL  1  (detail)  197
(48%)
MD130 + 5.6
(-)
35.4 + 3.2
(-)
197
(49%)
31.2 + 4.4
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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