MSGene

MSGene - Gene overview of all published MS-association studies for CD6

Gene:

CD6 (FLJ44171; TP120)

Protein:

CD6 molecule (CD6 antigen; T-cell differentiation antigen CD6; T12)

Chromosome:

11 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

1. Case-Control Studies (by ethnic group)
				MS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
De Jager, 2009	GWAS meta-analysis	CL	1 (detail)	-	MD1	-	-	-	-	Positive
De Jager, 2009	UK	CL	1 (detail)	831 (70%)	MD1	32 (10-67)	46 (-)	1030 (-)	-	Positive
De Jager, 2009	USA (UCSF)	CL	1 (detail)	407 (-)	MD1	42 (3-60)	54 (-)	142 (-)	-	Positive
De Jager, 2009	USA (BWH,WU,ACP,RUSH)	CL	1 (detail)	976 (-)	MD1	-	-	944 (-)	-	Positive
IMSGC, 2011	Belgium	CL	1 (detail)	1021 (64%)	O/M	-	-	776 (52%)	-	Positive
IMSGC, 2011	Denmark	CL	1 (detail)	1090 (67%)	O/M	-	-	634 (62%)	-	Negative
IMSGC, 2011	Finland	CL	1 (detail)	1077 (71%)	O/M	-	-	792 (58%)	-	Positive
IMSGC, 2011	Germany	CL	1 (detail)	911 (-)	O/M	-	-	930 (-)	-	Negative
IMSGC, 2011	Italy	CL	1 (detail)	629 (67%)	O/M	-	-	828 (50%)	-	Negative
IMSGC, 2011	Norway	CL	1 (detail)	1027 (72%)	O/M	-	-	662 (67%)	-	Negative
IMSGC, 2011	Spain	CL	1 (detail)	501 (64%)	O/M	-	-	501 (52%)	-	Negative
IMSGC, 2011	Sweden	CL	1 (detail)	1723 (71%)	O/M	-	-	2016 (67%)	-	Positive
IMSGC, 2011	UK	CL	1 (detail)	714 (74%)	O/M	-	-	656 (74%)	-	Negative
IMSGC, 2011	USA	CL	1 (detail)	587 (52%)	O/M	-	-	644 (52%)	-	Positive
Sanna, 2010	Italy-Sardinia (GWAS)	CL	1 (detail)	882 (-)	MD1	-	-	872 (-)	-	Negative
Swaminathan, 2010	Spain (Bilbao)	CL	1 (detail)	592 (73%)	P	30.5 + 10.1 (7-66)	-	567 (69%)	-	Positive
Swaminathan, 2010	Spain (Andalucia)	CL	1 (detail)	1021 (69%)	P	31.5 + 10.7 (13-68)	-	1276 (67%)	-	Positive
Swaminathan, 2010	Spain (Madrid)	CL	1 (detail)	652 (63%)	P	28.8 + 8.9 (3-56)	-	850 (53%)	-	Positive
Swaminathan, 2010	Spain (San Sebastian)	CL	1 (detail)	250 (62%)	P	31.6 + 10.3 (12-68)	-	249 (66%)	-	Positive
African Descent
Johnson, 2009	USA	CL	2 (detail)	918 (79%)	MD1	-	-	656 (71%)	-	Positive
Other/Mixed
Pandit, 2010	India	CL	1 (detail)	197 (48%)	MD1	30 + 5.6 (-)	35.4 + 3.2 (-)	197 (49%)	31.2 + 4.4 (-)	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.

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