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MSGene - Gene overview of all published MS-association studies for IL1B
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 Gene: IL1B  (IL-1; IL1-BETA; IL1F2)  Entrez Gene    View on AlzGene   View on PDGene   View on SZGene
 Protein: interleukin 1, beta  (catabolin; preinterleukin 1 beta; pro-interleukin-1-beta)  ProteinLink
 Chromosome: 2   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011 ;  ***Note that the RFLP Ava I in IL1B commonly referred to as nucleotide acid position "-511" can be assigned to two restriction sites each harboring one SNP (rs16944 and rs3087258) that both affect the restriction. Therefore this RFLP is excluded from meta-analysis.***
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Aggelakis, 2009
Greece CL  2  (detail)  351
(66%)
MD132.1 + 9.4
(-)
40.8 + 10.9
(-)
375
(63%)
40.1 + 10.8
(-)
Negative
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS) CL  4  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
Borzani, 2010
Italy CL  6  (detail)  160
(68%)
MD1-40.9 + 8.5
(-)
250
(60%)
-Positive
de Jong, 2002
Netherlands CL  1  (detail)  75
(60%)
P34 + 9
(-)
50 + 9
(-)
138
(-)
-Negative
Dincic, 2006
Serbia CL  1  (detail)  162
(62%)
MD129.9 + 9.3
(-)
36.5 + 10.7
(-)
103
(43%)
51.3 + 13.2
(-)
Negative
Ferri, 2000
Italy CL  1  (detail)  321
(63%)
P27.4 + 9.2
(-)
38 + 12
(-)
403
(36%)
38 + 10.9
(-)
Negative
Hooper-van Veen, 2003
Netherlands CL  2  (detail)  492
(62%)
P32 + 10
(-)
45 + 11
(-)
228
(-)
-Negative
Kantarci, 2000
USA CL,PO  1  (detail)  122
(43%)
U29.6 + 8.9
(-)
48.3
(-)
244
(-)
-Positive
Luomala, 2001
Finland CL  2  (detail)  93
(53%)
P32 + 8.1
(-)
-400
(-)
-Negative
Mann, 2002
UK CL  4  (detail)  444
(69%)
O/M32.2 + 9.1
(-)
44.6 + 10.1
(-)
151
(-)
-Trend
Mirowska-Guzel, 2011
Poland CL  1  (detail)  230
(73%)
MD1&229 + 9.9
(-)
38.1 + 10.9
(-)
195
(67%)
40 + 10.1
(-)
Positive
Motsinger, 2007
USA CL  2  (detail)  421
(-)
MD1--96
(-)
-Negative
Schrijver, 1999
Overlaps with
Hooper-van Veen, 2004
CL  1  (detail)  148
(58%)
P33.3 + 10
(-)
-98
(-)
-n.a.
Zhang, 2005
Sweden CL  1  (detail)  672
(72%)
P31.5
(-)
45.6
(15-80)
672
(49%)
54.5
(17-91)
Negative
 African Descent
Brassat, 2006
USA CL  2  (detail)  442
(-)
MD1--293
(-)
-Negative
 Asian
Niino, 2001
Japan CL  1  (detail)  98
(74%)
P26.1 + 8.8
(-)
35.7 + 10.8
(-)
104
(82%)
32.7 + 9.2
(-)
Negative
 Other/Mixed
Amirzargar, 2007
Iran CL  2  (detail)  44
(68%)
P--140
(-)
-Negative
Sarial, 2008
Iran CL  2  (detail)  100
(70%)
U38
(-)
35 + 7
(-)
140
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Barcellos, 2004
Overlaps with
Motsinger, 2007 (CC)
 2  (detail)  337337
(-)
U----Negative
Feakes, 2000
UK  1  (detail)  536536
(75%)
P25.5
(-)
38
(-)
1072
(50%)
-Negative
Motsinger, 2007
Overlaps with
Motsinger, 2007 (CC)
 2  (detail)  146146
(-)
MD1----n.a.
Wansen, 1997
Finland  1  (detail)  106106
(68%)
P-34
(17-52)
212
(50%)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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