MSGene

MSGene - Gene overview of all published MS-association studies for IFIH1

Gene:

IFIH1 (Hlcd; IDDM19; MDA-5; MDA5; MGC133047)

Protein:

interferon induced with helicase C domain 1 (DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; helicard; melanoma differentiation associated protein-5)

Chromosome:

2 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

1. Case-Control Studies (by ethnic group)
				MS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Baranzini, 2008	USA, Netherlands, Switzerland (GWAS)	CL	2 (detail)	978 (67%)	MD1&2	34 (11-61)	47 (21-69)	883 (66%)	46 (21-69)	Negative
Bergamaschi, 2010	Italy	CL	1 (detail)	827 (67%)	U	32.5 + 10.5 (-)	-	628 (-)	-	Negative
Bergamaschi, 2010	UK	CL	1 (detail)	2210 (73%)	U	29.8 + 9.4 (-)	-	10029 (-)	-	Negative
Enevold, 2009	Denmark	CL	3 (detail)	963 (68%)	P	-	39.3 (13-80)	960 (62%)	38 (14-80)	Positive
IMSGC, 2007	USA, UK (GWAS)	CL,PO	1 (detail)	931 (75%)	MD1&2	27.8 (10-51)	38.6 (17-59)	2431 (-)	-	Negative
IMSGC, 2009	Belgium	CL	1 (detail)	398 (-)	MD1&2	-	47 (-)	461 (-)	-	Negative
IMSGC, 2009	Norway	CL	1 (detail)	644 (-)	MD1&2	32 (-)	46.3 (-)	1023 (-)	-	Trend
IMSGC, 2009	Overlaps with WTCCC, 2007 (UK)	CL,PO	1 (detail)	2370 (-)	MD1&2	-	44.2 (-)	7078 (-)	-	n.a.
Martinez, 2008	Spain	CL	1 (detail)	412 (65%)	P	-	-	535 (51%)	-	Trend
WTCCC, 2007	Overlaps with IMSGC, 2007 (UK)	CL,PO	3 (detail)	994 (72%)	O/M	30.3 (10-60)	43.8 (17-79)	1466 (50%)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Couturier, 2009	France	1 (detail)	591	591 (70%)	O/M	-	-	-	-	Negative
IMSGC, 2009	Australia	1 (detail)	356	-	MD1&2	-	-	-	-	Negative
IMSGC, 2009	Belgium	1 (detail)	113	-	MD1&2	-	-	-	-	Trend
IMSGC, 2009	UK	1 (detail)	1143	-	MD1&2	-	-	-	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.

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