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MSGene - Gene overview of all published MS-association studies for LTA
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 Gene: LTA  (DAMA-25N12.13; LT; TNFB; TNFSF1)  Entrez Gene    View on ALSGene   View on AlzGene   View on SZGene
 Protein: lymphotoxin alpha (TNF superfamily, member 1)  (OTTHUMP00000165897; lymphotoxin alpha; tumor necrosis factor beta)  ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 30 January 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Alizadeh, 2003
Overlaps with
GAMES, 2006 (France)
CL  1  (detail)  200
(-)
P--200
(-)
-n.a.
Allcock, 1999
Spain CL  2  (detail)  218
(70%)
P--274
(63%)
-Trend
Ban, 2003
Overlaps with
GAMES, 2006 (Australia)
CL  1  (detail)  217
(84%)
P--187
(-)
-n.a.
Bielecki, 2003
Overlaps with
GAMES, 2006 (Poland)
CL  1  (detail)  200
(65%)
O/M29.7
(-)
40
(-)
200
(54%)
-n.a.
Coraddu, 2003
Overlaps with
GAMES, 2006 (Sardinia)
CL  1  (detail)  229
(-)
P--264
(-)
35.6
(-)
n.a.
de Jong, 2002
Netherlands CL  1  (detail)  159
(58%)
P30.3
(-)
44.3
(-)
273
(45%)
39 + 17
(-)
Positive
Epplen, 1995
Overlaps with
Epplen, 1997
CL  1  (detail)  350
(-)
U--300
(-)
-n.a.
Epplen, 1997
Germany CL  1  (detail)  358
(66%)
P29
(11-50)
-395
(29%)
38
(23-60)
Positive
Eraksoy, 2003
Overlaps with
GAMES, 2006 (Turkey)
CL  1  (detail)  197
(63%)
P28.4
(-)
39.3
(-)
199
(-)
-n.a.
Favorova, 2006
Russia CL  4  (detail)  286
(62%)
MD123 + 9
(-)
33 + 12
(-)
362
(44%)
30 + 11
(-)
Positive
Fernandez Filho, 2002
Norway CL  1  (detail)  133
(-)
P--148
(-)
-Positive
GAMES, 2006
Multiple CL  1  (detail)  3447
(-)
O/M--3292
(-)
-Positive
Goedde, 2002
Overlaps with
GAMES, 2006 (Germany2)
CL  1  (detail)  198
(-)
P29.9 + 9.6
(-)
43.5 + 11.4
(-)
198
(-)
40.3 + 9.9
(-)
n.a.
Goertsches, 2003
Overlaps with
GAMES, 2006 (Spain)
CL  1  (detail)  200
(67%)
O/M27 + 8
(-)
34.9
(-)
200
(-)
-n.a.
Goris, 2003
Overlaps with
GAMES, 2006 (Belgium)
CL  1  (detail)  204
(62%)
P--198
(42%)
-n.a.
Harbo, 2003
Overlaps with
GAMES, 2006 (Scandinavia)
CL  1  (detail)  400
(-)
P--400
(-)
-n.a.
Heggarty, 2003
Overlaps with
GAMES, 2006 (Northern Ireland)
CL  1  (detail)  200
(70%)
P27
(-)
-200
(53%)
-n.a.
Jonasdottir, 2003
Overlaps with
GAMES, 2006 (Iceland)
CL  1  (detail)  200
(71%)
P-52.2
(-)
200
(43%)
45.7
(-)
n.a.
Kirk, 1997
UK (Northern Ireland) CL  3  (detail)  189
(-)
U--206
(-)
-Positive
Laaksonen, 2003
Overlaps with
GAMES, 2006 (Finland)
CL  1  (detail)  195
(68%)
P--205
(69%)
-n.a.
Liguori, 2003
Overlaps with
GAMES, 2006 (Italy)
CL  1  (detail)  224
(-)
P--231
(-)
-n.a.
Lucotte, 2000
France CL  1  (detail)  74
(58%)
P--75
(-)
-Positive
Martinez, 2004
Spain CL  2  (detail)  241
(66%)
P-34 + 8
(-)
288
(61%)
-Positive
Martins Silva, 2003
Overlaps with
GAMES, 2006 (Portugal2)
CL  1  (detail)  200
(67%)
P27.6
(6-60)
37
(16-73)
200
(-)
-n.a.
McDonnell, 1999a
Ireland CL  2  (detail)  276
(65%)
P32.8
(-)
-216
(-)
-Positive
Motsinger, 2007
USA CL  1  (detail)  421
(-)
MD1--96
(-)
-Negative
Mycko, 1998
Poland CL  2  (detail)  53
(-)
P--66
(-)
-Positive
Rajda, 2003
Overlaps with
GAMES, 2006 (Hungary)
CL  1  (detail)  88
(78%)
P-35
(-)
128
(72%)
-n.a.
Sandberg-Wollheim, 1995
Sweden CL  2  (detail)  122
(-)
P--178
(-)
-Positive
Santos, 2003
Overlaps with
GAMES, 2006 (Portugal1)
CL  1  (detail)  188
(69%)
P-37
(17-64)
188
(69%)
-n.a.
Sawcer, 2002
Overlaps with
GAMES, 2006 (UK)
CL  1  (detail)  216
(-)
O/M--219
(-)
-n.a.
Vandevyver, 1994
Belgium CL  1  (detail)  51
(-)
P--58
(-)
-Trend
Weber, 2003
Overlaps with
GAMES, 2006 (Germany1)
CL  1  (detail)  234
(72%)
P-35.9
(-)
209
(52%)
-n.a.
 African Descent
Brassat, 2006
USA CL  1  (detail)  442
(-)
MD1--293
(-)
-Negative
 Asian
Ma, 1998
Japan CL  2  (detail)  80
(68%)
P29 + 9
(-)
42
(-)
85
(-)
-Negative
 Other/Mixed
Kamali-Sarvestani, 2007
Iran CL  1  (detail)  270
(76%)
P26.3 + 6.9
(-)
31
(-)
542
(74%)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Alizadeh, 2003
Overlaps with
GAMES, 2006 (France)
 1  (detail)  200-P----n.a.
Bielecki, 2003
Overlaps with
GAMES, 2006 (Poland)
 1  (detail)  129-O/M----n.a.
Coraddu, 2003
Overlaps with
GAMES, 2006 (Sardinia)
 1  (detail)  235-P----n.a.
GAMES, 2006
Multiple  1  (detail)  1596-O/M----Positive
Goris, 2003
Overlaps with
GAMES, 2006 (Belgium)
 1  (detail)  131131
(62%)
P--262
(50%)
-n.a.
Liguori, 2003
Overlaps with
GAMES, 2006 (Italy)
 1  (detail)  185185
(-)
P--370
(50%)
-n.a.
Sawcer, 2002
Overlaps with
GAMES, 2006 (UK)
 1  (detail)  745-O/M--1490
(50%)
-n.a.
Weber, 2003
Overlaps with
GAMES, 2006 (Germany1)
 1  (detail)  6868
(79%)
P-34.2
(-)
136
(50%)
-n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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