MSGene

MSGene - Gene overview of all published MS-association studies for LTA

Gene:

LTA (DAMA-25N12.13; LT; TNFB; TNFSF1)

View on ALSGene View on AlzGene View on SZGene

Protein:

lymphotoxin alpha (TNF superfamily, member 1) (OTTHUMP00000165897; lymphotoxin alpha; tumor necrosis factor beta)

Chromosome:

6 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 30 January 2011

1. Case-Control Studies (by ethnic group)
				MS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Alizadeh, 2003	Overlaps with GAMES, 2006 (France)	CL	1 (detail)	200 (-)	P	-	-	200 (-)	-	n.a.
Allcock, 1999	Spain	CL	2 (detail)	218 (70%)	P	-	-	274 (63%)	-	Trend
Ban, 2003	Overlaps with GAMES, 2006 (Australia)	CL	1 (detail)	217 (84%)	P	-	-	187 (-)	-	n.a.
Bielecki, 2003	Overlaps with GAMES, 2006 (Poland)	CL	1 (detail)	200 (65%)	O/M	29.7 (-)	40 (-)	200 (54%)	-	n.a.
Coraddu, 2003	Overlaps with GAMES, 2006 (Sardinia)	CL	1 (detail)	229 (-)	P	-	-	264 (-)	35.6 (-)	n.a.
de Jong, 2002	Netherlands	CL	1 (detail)	159 (58%)	P	30.3 (-)	44.3 (-)	273 (45%)	39 + 17 (-)	Positive
Epplen, 1995	Overlaps with Epplen, 1997	CL	1 (detail)	350 (-)	U	-	-	300 (-)	-	n.a.
Epplen, 1997	Germany	CL	1 (detail)	358 (66%)	P	29 (11-50)	-	395 (29%)	38 (23-60)	Positive
Eraksoy, 2003	Overlaps with GAMES, 2006 (Turkey)	CL	1 (detail)	197 (63%)	P	28.4 (-)	39.3 (-)	199 (-)	-	n.a.
Favorova, 2006	Russia	CL	4 (detail)	286 (62%)	MD1	23 + 9 (-)	33 + 12 (-)	362 (44%)	30 + 11 (-)	Positive
Fernandez Filho, 2002	Norway	CL	1 (detail)	133 (-)	P	-	-	148 (-)	-	Positive
GAMES, 2006	Multiple	CL	1 (detail)	3447 (-)	O/M	-	-	3292 (-)	-	Positive
Goedde, 2002	Overlaps with GAMES, 2006 (Germany2)	CL	1 (detail)	198 (-)	P	29.9 + 9.6 (-)	43.5 + 11.4 (-)	198 (-)	40.3 + 9.9 (-)	n.a.
Goertsches, 2003	Overlaps with GAMES, 2006 (Spain)	CL	1 (detail)	200 (67%)	O/M	27 + 8 (-)	34.9 (-)	200 (-)	-	n.a.
Goris, 2003	Overlaps with GAMES, 2006 (Belgium)	CL	1 (detail)	204 (62%)	P	-	-	198 (42%)	-	n.a.
Harbo, 2003	Overlaps with GAMES, 2006 (Scandinavia)	CL	1 (detail)	400 (-)	P	-	-	400 (-)	-	n.a.
Heggarty, 2003	Overlaps with GAMES, 2006 (Northern Ireland)	CL	1 (detail)	200 (70%)	P	27 (-)	-	200 (53%)	-	n.a.
Jonasdottir, 2003	Overlaps with GAMES, 2006 (Iceland)	CL	1 (detail)	200 (71%)	P	-	52.2 (-)	200 (43%)	45.7 (-)	n.a.
Kirk, 1997	UK (Northern Ireland)	CL	3 (detail)	189 (-)	U	-	-	206 (-)	-	Positive
Laaksonen, 2003	Overlaps with GAMES, 2006 (Finland)	CL	1 (detail)	195 (68%)	P	-	-	205 (69%)	-	n.a.
Liguori, 2003	Overlaps with GAMES, 2006 (Italy)	CL	1 (detail)	224 (-)	P	-	-	231 (-)	-	n.a.
Lucotte, 2000	France	CL	1 (detail)	74 (58%)	P	-	-	75 (-)	-	Positive
Martinez, 2004	Spain	CL	2 (detail)	241 (66%)	P	-	34 + 8 (-)	288 (61%)	-	Positive
Martins Silva, 2003	Overlaps with GAMES, 2006 (Portugal2)	CL	1 (detail)	200 (67%)	P	27.6 (6-60)	37 (16-73)	200 (-)	-	n.a.
McDonnell, 1999a	Ireland	CL	2 (detail)	276 (65%)	P	32.8 (-)	-	216 (-)	-	Positive
Motsinger, 2007	USA	CL	1 (detail)	421 (-)	MD1	-	-	96 (-)	-	Negative
Mycko, 1998	Poland	CL	2 (detail)	53 (-)	P	-	-	66 (-)	-	Positive
Rajda, 2003	Overlaps with GAMES, 2006 (Hungary)	CL	1 (detail)	88 (78%)	P	-	35 (-)	128 (72%)	-	n.a.
Sandberg-Wollheim, 1995	Sweden	CL	2 (detail)	122 (-)	P	-	-	178 (-)	-	Positive
Santos, 2003	Overlaps with GAMES, 2006 (Portugal1)	CL	1 (detail)	188 (69%)	P	-	37 (17-64)	188 (69%)	-	n.a.
Sawcer, 2002	Overlaps with GAMES, 2006 (UK)	CL	1 (detail)	216 (-)	O/M	-	-	219 (-)	-	n.a.
Vandevyver, 1994	Belgium	CL	1 (detail)	51 (-)	P	-	-	58 (-)	-	Trend
Weber, 2003	Overlaps with GAMES, 2006 (Germany1)	CL	1 (detail)	234 (72%)	P	-	35.9 (-)	209 (52%)	-	n.a.
African Descent
Brassat, 2006	USA	CL	1 (detail)	442 (-)	MD1	-	-	293 (-)	-	Negative
Asian
Ma, 1998	Japan	CL	2 (detail)	80 (68%)	P	29 + 9 (-)	42 (-)	85 (-)	-	Negative
Other/Mixed
Kamali-Sarvestani, 2007	Iran	CL	1 (detail)	270 (76%)	P	26.3 + 6.9 (-)	31 (-)	542 (74%)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Alizadeh, 2003	Overlaps with GAMES, 2006 (France)	1 (detail)	200	-	P	-	-	-	-	n.a.
Bielecki, 2003	Overlaps with GAMES, 2006 (Poland)	1 (detail)	129	-	O/M	-	-	-	-	n.a.
Coraddu, 2003	Overlaps with GAMES, 2006 (Sardinia)	1 (detail)	235	-	P	-	-	-	-	n.a.
GAMES, 2006	Multiple	1 (detail)	1596	-	O/M	-	-	-	-	Positive
Goris, 2003	Overlaps with GAMES, 2006 (Belgium)	1 (detail)	131	131 (62%)	P	-	-	262 (50%)	-	n.a.
Liguori, 2003	Overlaps with GAMES, 2006 (Italy)	1 (detail)	185	185 (-)	P	-	-	370 (50%)	-	n.a.
Sawcer, 2002	Overlaps with GAMES, 2006 (UK)	1 (detail)	745	-	O/M	-	-	1490 (50%)	-	n.a.
Weber, 2003	Overlaps with GAMES, 2006 (Germany1)	1 (detail)	68	68 (79%)	P	-	34.2 (-)	136 (50%)	-	n.a.

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.

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