MSGene

MSGene - Gene overview of all published MS-association studies for MBP

Gene:

MBP (MGC99675)

View on SZGene

Protein:

myelin basic protein (Golli-mbp; OTTHUMP00000174383)

Chromosome:

18 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 22 July 2010

1. Case-Control Studies (by ethnic group)
				MS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Boylan, 1990	Canada	PO	1 (detail)	65 (69%)	P	-	36.1 (23-65)	63 (46%)	69.6 (50-99)	Positive
Eoli, 1994	Italy	CL	1 (detail)	54 (63%)	P	-	32.3 + 9.7 (-)	55 (60%)	38.6 + 12.9 (-)	Negative
Graham, 1993	UK (Northern Ireland)	CL	1 (detail)	122 (-)	U	-	-	106 (-)	-	Negative
Guerini, 2000	Italy	CL	1 (detail)	171 (67%)	U	-	-	236 (61%)	-	Positive
Guerini, 2003	Russia	CL	1 (detail)	126 (52%)	P	23 + 9 (-)	32 + 11 (-)	142 (62%)	28 + 10 (-)	Positive
Guerini, 2003	Overlaps with Guerini, 2000	CL	1 (detail)	143 (62%)	P	28 + 10 (-)	30 + 10 (-)	243 (60%)	40 + 10 (-)	n.a.
He, 1998	Sweden	CL	1 (detail)	149 (-)	U	-	-	95 (-)	-	Negative
Ibsen, 1995	Overlaps with Ibsen, 1996	CL	1 (detail)	64 (55%)	P	-	55 (-)	57 (74%)	51 (-)	n.a.
Ibsen, 1996	Denmark	CL	1 (detail)	90 (60%)	P	-	54 (-)	106 (-)	-	Positive
Nellemann, 1995	Denmark	CL	1 (detail)	34 (76%)	P	-	-	200 (84%)	-	Negative
Price, 1997	UK	CL	11 (detail)	77 (73%)	U	-	40 (23-69)	71 (-)	-	Negative
Szolnoki, 2008	Hungary	CL	12 (detail)	52 (-)	P	-	-	97 (-)	-	Negative
Tienari, 1992	Overlaps with Tienari, 1998	CL	1 (detail)	72 (61%)	P	32 (-)	43 (22-79)	85 (-)	-	n.a.
Tienari, 1998	Finland	CL	4 (detail)	74 (59%)	P	-	45 (24-81)	85 (-)	-	Positive
Vandevyver, 1994	Belgium	CL	1 (detail)	67 (-)	U	-	-	72 (-)	-	Negative
Wood, 1994	UK	CL	1 (detail)	77 (-)	P	-	-	88 (-)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Cocco, 2002	Italy (Sardinia)	1 (detail)	363	363 (69%)	P	-	32.7 (12-65)	726 (50%)	-	Negative
Coppin, 2000	France	1 (detail)	196	242 (-)	O/M	-	-	-	-	Negative
Pihlaja, 2003	Finland (other)	1 (detail)	251	-	P	-	-	-	-	Negative
Pihlaja, 2003	Finland (Bothnia)	1 (detail)	98	-	P	-	-	-	-	Positive
Tienari, 1998	Sweden	4 (detail)	35	57 (-)	O/M	-	-	118 (-)	-	Negative
Tienari, 1998	Finland	4 (detail)	116	132 (-)	P	-	-	333 (-)	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.

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