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MSGene - Gene overview of all published MS-association studies for IL4R
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 Gene: IL4R (CD124; IL4RA)   View on SZGene
 Protein: interleukin 4 receptor(OTTHUMP00000122506; interleukin 4 receptor alpha chain; interleukin-4 receptor alpha chain)
 Chromosome: 16   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Aulchenko, 2008
Netherlands (GWAS) CL  4  (detail)  45
(-)
O/M--195
(-)
-Negative
Ban, 2009
Belgium CL  1  (detail)  368
(-)
O/M--374
(-)
-Negative
Ban, 2009
Norway CL  1  (detail)  638
(-)
O/M32
(-)
46.3
(-)
1026
(-)
-Positive
Ban, 2009
UK (I) CL  1  (detail)  475
(-)
O/M--479
(-)
-Negative
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS) CL  9  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
Hackstein, 2001
Germany CL  6  (detail)  341
(66%)
O/M29.9
(-)
40.3
(-)
305
(46%)
-Positive
IMSGC, 2007
USA, UK (GWAS) CL,PO  5  (detail)  931
(75%)
MD1&227.8
(10-51)
38.6
(17-59)
2431
(-)
-Negative
Motsinger, 2007
USA CL  3  (detail)  421
(-)
MD1--96
(-)
-Negative
Nohra, 2010
Norway CL  3  (detail)  548
(72%)
U-54
(22-90)
554
(54%)
46.6
(34-58)
Negative
Nohra, 2010
Sweden (I) CL  23  (detail)  1018
(84%)
MD1-53
(22-91)
1215
(63%)
47
(21-76)
Positive
Nohra, 2010
Sweden (II) CL  5  (detail)  1293
(67%)
U31.5
(11-64)
37
(-)
663
(77%)
-Negative
Quirico-Santos, 2007
Brazil CL  1  (detail)  74
(-)
MD1--88
(-)
-Negative
Suppiah, 2005
Ireland CL  1  (detail)  267
(59%)
P33.1 + 11.3
(-)
-179
(-)
-Negative
Suppiah, 2005
Spain CL  1  (detail)  191
(74%)
P28 + 9.1
(-)
-94
(-)
-Negative
WTCCC, 2007
UK (GWAS) CL,PO  4  (detail)  994
(72%)
O/M30.3
(10-60)
43.8
(17-79)
1466
(50%)
-Negative
 African Descent
Brassat, 2006
USA CL  3  (detail)  442
(-)
MD1--293
(-)
-Positive
Quirico-Santos, 2007
Brazil CL  1  (detail)  55
(-)
MD1--47
(-)
-Positive
 Other/Mixed
Amirzargar, 2007
Iran CL  1  (detail)  44
(68%)
P--140
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Ban, 2009
Belgium  1  (detail)  113-O/M----Negative
Ban, 2009
UK (I)  1  (detail)  693-O/M----Negative
Barcellos, 2004
Overlaps with
Motsinger, 2007 (CC)
 3  (detail)  337337
(-)
U----Negative
Mirel, 2004
Overlaps with
Motsinger, 2007 (CC)
 3  (detail)  332332
(74%)
U27.1 + 7.9
(-)
35.9
(-)
--Positive
Mirel, 2004
USA  6  (detail)  332332
(74%)
U27.1 + 7.9
(-)
35.9
(-)
--Positive
Motsinger, 2007
Overlaps with
Motsinger, 2007 (CC)
 3  (detail)  146146
(-)
MD1----n.a.
Suppiah, 2005
Belgium  1  (detail)  126126
(60%)
P28.2 + 8
(-)
-126
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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