MSGene

MSGene - Gene overview of all published MS-association studies for PDE4B

Gene:

PDE4B (RP5-876C12.1; DKFZp686F2182; DPDE4; MGC126529; PDE4B5; PDEIVB)

View on SZGene

Protein:

phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) (OTTHUMP00000010652; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific phosphodiesterase-4 B isoform; dunce-like phosphodiesterase E4; phosphodiesterase 4B; phosphodiesterase 4B, cAMP-specific (dunce)

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 November 2011

1. Case-Control Studies (by ethnic group)
				MS Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
D'Netto, 2009	Canada	CL	1 (detail)	43 (-)	U	-	-	182 (-)	-	Negative
Hoppenbrouwers, 2008	Overlaps with Hoppenbrouwers, 2009	CL	1 (detail)	46 (72%)	U	33 + 11 (-)	-	194 (-)	-	n.a.
Hoppenbrouwers, 2009	Netherlands (isolated)	CL	1 (detail)	45 (-)	O/M	-	-	195 (-)	-	Positive
Hoppenbrouwers, 2009	Netherlands (outbred)	CL	1 (detail)	490 (-)	O/M	-	-	426 (-)	-	Negative
IMSGC, 2007	UK	CL	1 (detail)	928 (73%)	MD1&2	32.6 (13-60)	45.1 (17-79)	1475 (-)	-	Positive
IMSGC, 2007	USA	CL	1 (detail)	1394 (73%)	MD1&2	33.1 (3-69)	45.4 (18-74)	1512 (-)	-	Positive
IMSGC, 2007	USA, UK (GWAS)	CL,PO	1 (detail)	931 (75%)	MD1&2	27.8 (10-51)	38.6 (17-59)	2431 (-)	-	Positive
Rubio, 2008	Australia	CL	1 (detail)	1146 (75%)	O/M	32 (7-67)	-	1309 (-)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
D'Netto, 2009	Overlaps with D'Netto, 2009 (CC)	1 (detail)	43	211 (-)	U	-	-	-	-	Negative
Hoppenbrouwers, 2009	Canada	1 (detail)		1318 (-)	O/M	-	-	1507 (-)	-	Negative
IMSGC, 2007	UK	1 (detail)	380	380 (75%)	MD1&2	27.4 (10-53)	37.4 (17-58)	-	-	Positive
IMSGC, 2007	USA	1 (detail)	229	229 (79%)	MD1&2	31.1 (9-51)	39.4 (19-58)	-	-	Positive
IMSGC, 2007	Overlaps with IMSGC, 2007 (UK-GWAS, CC)	1 (detail)	453	453 (75%)	MD1&2	26.5 (10-48)	38.2 (19-59)	-	-	Positive
IMSGC, 2007	Overlaps with IMSGC, 2007 (USA-GWAS, CC)	1 (detail)	478	478 (74%)	MD1&2	29 (11-51)	39 (17-57)	-	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis -> "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.

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