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MSGene - Gene overview of all published MS-association studies for FAS
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 Gene: FAS (ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6)   View on AlzGene
 Protein: Fas (TNF receptor superfamily, member 6)(APO-1 cell surface antigen; CD95 antigen; Fas AMA; Fas antigen; apoptosis antigen 1; tumor necrosis factor receptor superfamily, member 6)
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Aulchenko, 2008
Netherlands (GWAS) CL  1  (detail)  45
(-)
O/M--195
(-)
-Negative
Baranzini, 2008
USA, Netherlands, Switzerland (GWAS) CL  1  (detail)  978
(67%)
MD1&234
(11-61)
47
(21-69)
883
(66%)
46
(21-69)
Negative
Cascino, 1998
Italy CL  2  (detail)  62
(-)
P--111
(-)
-Negative
Huang, 2000
Australia CL  1  (detail)  124
(-)
P--183
(-)
-Trend
IMSGC, 2007
USA, UK (GWAS) CL,PO  1  (detail)  931
(75%)
MD1&227.8
(10-51)
38.6
(17-59)
2431
(-)
-Negative
Kantarci, 2004
USA CL,PO  3  (detail)  221
(71%)
U--442
(-)
-Positive
Lucas, 2004
Spain CL  2  (detail)  312
(65%)
P33.2
(-)
39.8
(-)
215
(-)
-Positive
van Veen, 2002
Netherlands CL  1  (detail)  382
(63%)
P32 + 10
(-)
49 + 11
(-)
206
(63%)
38
(-)
Positive
 Asian
Niino, 2002
Japan CL  1  (detail)  114
(74%)
MD126.2 + 9
(-)
35 + 10.7
(-)
121
(76%)
33.1 + 9.2
(20-58)
Negative
 Other/Mixed
Mohammadzadeh, 2011
Iran CL  1  (detail)  107
(77%)
U-35 + 9.9
(-)
112
(74%)
34 + 10.3
(-)
Trend
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Lucas, 2004
Spain  2  (detail)  67-U----Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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