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MSGene - Gene overview of all published MS-association studies for KIR2DL3
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 Gene: KIR2DL3 (CU464054.1; CD158B2; CD158b; GL183; KIR-023GB; KIR-K7b; KIR-K7c; KIRCL23; MGC129943; NKAT; NKAT2; NKAT2A; NKAT2B; p58)
 Protein: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3(NK-receptor; killer cell immunoglobulin-like receptor 2DL3; natural killer associated transcript 2; natural killer cell inhibitory receptor KIR2DL3; p58 natural killer cell receptor; p58.2 MHC class-I specific NK receptor)
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 23 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Fusco, 2010
Italy CL  1  (detail)  121
(63%)
P26
(12-50)
38
(-)
103
(54%)
-Negative
Garcia-Leon, 2011
Spain CL  1  (detail)  200
(70%)
MD129.4 + 10.5
(8-61)
42.3 + 10.7
(18-70)
200
(-)
-Negative
Lorentzen, 2009
Norway CL  1  (detail)  631
(72%)
O/M--555
(66%)
-Negative
Ordonez, 2009
Spain (I+II) CL  1  (detail)  224
(30%)
MD128.3 + 8.7
(11-65)
40.3 + 9.8
(19-68)
289
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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