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MSGene - Gene overview of all published MS-association studies for APOE
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 Gene: APOE  (AD2; LDLCQ5; LPG; MGC1571)  Entrez Gene    View on ALSGene   View on AlzGene   View on PDGene   View on SZGene
 Protein: apolipoprotein E  (apolipoprotein E3)  ProteinLink
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 24 July 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      MS Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Ballerini, 2000
Italy CL  2  (detail)  66
(70%)
P27.8 + 6.1
(-)
43 + 10
(-)
67
(52%)
40 + 5
(-)
Positive
Barcellos, 1997
USA CL  1  (detail)  120
(-)
O/M--107
(-)
-Trend
Carlin, 2000
UK (Scotland) CL  2  (detail)  71
(58%)
O/M-58.5
(31-89)
41
(-)
50.8
(18-82)
Negative
Chapman, 2001
Israel CL  1  (detail)  205
(64%)
P34.4 + 0.9
(-)
-154
(-)
-Positive
Fazekas, 2001
Austria CL  2  (detail)  374
(70%)
P-40 + 10.8
(-)
389
(50%)
60.1 + 6.1
(50-70)
Positive
Ferri, 1999
Italy CL  2  (detail)  161
(67%)
U-40.9 + 11.3
(-)
153
(32%)
56.2 + 5.3
(-)
Negative
Gaillard, 1998
France CL  2  (detail)  70
(76%)
P--99
(47%)
-Negative
Hogh, 2000
Denmark CL,PO  2  (detail)  240
(65%)
U30 + 9.3
(-)
41.7 + 10
(19-80)
361
(51%)
50 + 0
(50-50)
n.a.
Koutsis, 2007
Greece CL  2  (detail)  212
(64%)
MD230.1 + 9.9
(10-64)
38.7 + 10.4
(16-69)
216
(32%)
35.6 + 11.5
(-)
Negative
Lucotte, 2000
France CL  2  (detail)  100
(57%)
P30
(16-59)
-248
(-)
-Positive
Pirttila, 2000
Finland CL  2  (detail)  105
(68%)
P34 + 10
(-)
39 + 10
(-)
1919
(-)
-Negative
Ramsaransing, 2005
Netherlands CL  2  (detail)  82
(67%)
P32.3 + 8.5
(-)
49.9 + 9.4
(-)
29
(52%)
44 + 10.1
(-)
Negative
Rosche, 2004
Germany CL  2  (detail)  267
(71%)
O/M-41 + 12.4
(-)
227
(57%)
41.5 + 16.3
(-)
Negative
Rubinsztein, 1994
UK (England) CL  2  (detail)  36
(64%)
P-58
(-)
91
(37%)
56
(-)
Negative
Santos, 2004
Portugal CL  2  (detail)  243
(70%)
P29 + 9.7
(-)
38.3 + 10.8
(-)
192
(-)
-Positive
Savettieri, 2003
Italy CL,PO  2  (detail)  428
(62%)
P27.3 + 8.3
(-)
38 + 9.3
(-)
107
(48%)
-Negative
Weatherby, 2000a
UK (England) CL  2  (detail)  370
(75%)
P31 + 9.1
(-)
43.8 + 11.2
(-)
159
(60%)
45.6 + 12.8
(-)
Negative
Zakrzewska-Pniewska, 2004
Poland CL  2  (detail)  117
(63%)
MD131.2
(-)
44.1 + 11.8
(18-73)
100
(59%)
74.2 + 5.6
(62-95)
Negative
Zwemmer, 2004
Netherlands CL  2  (detail)  408
(61%)
P32 + 10
(-)
46 + 11
(-)
144
(50%)
41
(-)
Negative
 Asian
Barcellos, 1997
China CL  1  (detail)  32
(-)
O/M--32
(-)
-Positive
Niino, 2003
Japan CL  2  (detail)  135
(72%)
MD126.8 + 9.3
(-)
34.9 + 10.7
(-)
134
(68%)
32.8 + 8.9
(20-58)
Negative
 Other/Mixed
Al-Shammri, 2005
Kuwait CL  2  (detail)  39
(56%)
P--106
(-)
-Trend
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine MS diagnosis ->  "P" (Poser criteria, 1983), "MD1" (McDonald criteria, 2001), "MD2" (revised McDonald criteria, 2005), "MD1&2" (McDonald criteria, 2001 and 2005), "O/M" (other/mixed), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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MSGene Stats
Studies: 789
Genes: 809
Polymorphisms: 2907
Meta-analyses: 324
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